Systems Medicine of the Liver

The König lab uses Systems Medicine and Systems Biology to study drug metabolism and liver function. We apply computational modeling, data science, data management, bioinformatics analysis and machine learning on biological, medical and clinical data.

Main research topics are (i) predictive modeling of biomedical systems with special focus on the liver; (ii) development of digital twins using physiologically based pharmacokinetic (PBPK) models, (iii) reproducible and open research, and (iv) FAIR data and workflows.

Key projects are the personalized evaluation of liver function tests, multi-scale modeling of the liver, and development of databases and workflows to support reproducible, open and FAIR research. Within our research we generate predictive digital twins of the individual human physiology. Such models can provide important insights in inter-individual differences and personal treatments, e.g., individual dosing of medication or effect of lifestyle factors on drug metabolism. For more information have a look at our publications and projects.

Interested in joining the lab, have a look at the open positions.


Group Leader
Dr. Matthias König

Systems Medicine of the Liver
Institute for Biology, Institute for Theoretical Biology
Humboldt Universität zu Berlin
Philippstraße 13, 10115 Berlin, Germany
+49 30 2093-98435


For more information have a look at our funding information.



2023-02-03 Preprint: Simvastatin therapy in different subtypes of hypercholesterolemia

Our latest preprint is now on medRxiv: Simvastatin therapy in different subtypes of hypercholesterolemia - a physiologically based modelling approach.

2023-02-01 ATLAS - AI and Simulation for Tumor Liver ASsessment

The BMBF is funding our joint project ATLAS in the "Computational Life Sciences - AI Methods for Systems Medicine".

2022-11-17 New Bachelor Student - Afruja Hossain

Afruja Hossain started in our lab working on a systematic overview of protein variability of cytochrome P450 (CYP450) isoforms in the human liver.

2022-11-15 Visiting EU parliament and attending STOA AI session

We were selected to participate in an European policy journey on the topic EU research funding and science communication by the Berlin University Alliance (BUA).

2022-10-24 Dextromethorphan Publication

How does CYP2D6 genotype effect metabolic phenotyping? See our latest paper in Frontiers in Pharmacology for answers.

2022-10-24 X-Research Group

M. König receives funding of the Berlin University Alliance and the DFG for the X-Student Research Group: Physiologically based modeling of drugs: ACE inhibitors

2022-10-06 COMBINE 2022

We organized the Computational Modeling in Biology Network (COMBINE) meeting in Berlin this year with > 100 participants from 06-08 October 2022.

For more news see news.