Systems Medicine of the Liver
The König lab uses Systems Medicine and Systems Biology to study drug metabolism and liver function. We apply computational modeling, data science, data management, bioinformatics analysis and machine learning on biological, medical and clinical data.
Main research topics are (i) predictive modeling of biomedical systems with special focus on the liver; (ii) development of digital twins using physiologically based pharmacokinetic (PBPK) models, (iii) reproducible and open research, and (iv) FAIR data and workflows.
Key projects are the personalized evaluation of liver function tests, multi-scale modeling of the liver, and development of databases and workflows to support reproducible, open and FAIR research. Within our research we generate predictive digital twins of the individual human physiology. Such models can provide important insights in inter-individual differences and personal treatments, e.g., individual dosing of medication or effect of lifestyle factors on drug metabolism. For more information have a look at our publications and projects.
Interested in joining the lab, have a look at the open positions.
Contact
Group Leader
Dr. Matthias König
Systems Medicine of the Liver
Institute for Biology, Institute for Theoretical Biology
Humboldt Universität zu Berlin
Philippstraße 13, 10115 Berlin, Germany
+49 30 2093-98435
koenigmx@hu-berlin.de
Funding
For more information have a look at our funding information.
News
2023-02-03 Preprint: Simvastatin therapy in different subtypes of hypercholesterolemia
2023-02-01 ATLAS - AI and Simulation for Tumor Liver ASsessment
2022-11-17 New Bachelor Student - Afruja Hossain
2022-11-15 Visiting EU parliament and attending STOA AI session
2022-10-24 Dextromethorphan Publication
2022-10-24 X-Research Group
2022-10-06 COMBINE 2022
