Monika is developing a PBPK model of immune suppressant rapamycin (sirolimus) as part of our contribution to the Immune Digital Twin (IDT).

Juan Pablo is developing a closed-loop control system to optimize anesthesia delivery, aiming to enhance precision and patient safety during surgical procedures.

Ennie develops a physiologically based pharmacokinetic/ pharmacodynamic (PBPK) model of the direct angiotensin II receptor (ARB) inhibitor losartan. The objective is to enhance our...

Elisabetta develops a physiologically based pharmacokinetic/ pharmacodynamic (PBPK) model of the direct oral anticoagulant (DOAC) rivaroxaban. The objective is to enhance our understanding of...

Helen worked on a physiologically based model of pravastatin. Key questions are the effect of genotypes and hepatic and renal disease on pravastatin pharmacokinetics...

Nike develops a physiologically based pharmacokinetic/ pharmacodynamic (PBPK) model of SGLT2 inhibitor dapagliflozin. The objective is to enhance our understanding of the underlying causes...

Isabella is building a PBPK/PD model of the GLP-1 receptor agonist liraglutide to explore its pharmacological behavior and impact on glucose homeostasis, with a...

During Program Day at Humboldt-Universität zu Berlin, Isabella Tan, Olivia Yau, and Minjun Kim presented their physiologically based pharmacokinetic/ pharmacodynamic (PBPK/PD) modeling projects on...

Rohini supports the data curation for morphine pharmacokinetics.

Rohit supports the data curation for morphine pharmacokinetics.

Emre works on CySBML Reloaded: Smarter, Simpler, Automated, a project focused on upgrading CySBML — a Cytoscape app for visualizing computational models encoded in...

Michael Gaas is enhancing the Systems Biology Simulation Core Library (SBSCL) by developing a solver-agnostic framework that enables seamless integration of open-source and commercial...

Abhinav develops a physiologically based pharmacokinetic (PBPK) model of the GIP and GLP-1 receptor agonist tirzepatide (Mounjaro). The objective is to enhance our understanding...

Yusuf works on a physiologically based pharmacokinetic/ pharmacodynamic model of the direct renin inhibitor aliskiren.

Luca works on a physiologically based model of the oral contraceptive component ethinylestradiol. By the end of this project, we offer a robust and...

Jennesse develops a physiologically based pharmacokinetic/ pharmacodynamic (PBPK) model of SGLT2 inhibitor canagliflozin. The objective is to enhance our understanding of the underlying causes...

Deepa worked on a kinetic model of glucose stimulated insulin secretion (GSIS) of the pancreatic beta-cell, studying changes in glycolysis during insulin secretion, and...

Beatrice works on a physiologically based model to characterize intestinal P-glycoprotein using talinolol as a probe drug.

Vera developed a physiologically based pharmacokinetic/ pharmacodynamic (PBPK) model of SGLT2 inhibitor canagliflozin. The objective is to enhance our understanding of the underlying causes...

Samira works to enhance our understanding of the role of endoglin in TGF-β signaling. She develops a computational model that explores the nuances of...

Jonas worked on a physiologically based model of chlorzoxazone for hepatic CYP2E1 phenotyping. Key questions are the effect of CYP2E1 induction/inhibition and zonation on...

Prerna worked on an advanced Large Language Model (LLM) to serve as an expert system for efficiently and accurately curating pharmacokinetic data from scientific...

Afruja worked on a systematic overview of the protein variability of cytochrome P450 (CYP450) isoforms in the human liver.

Hannah will establish a pharmacokinetic dataset of semaglutide and develop an initial version of a physiologically based pharmacokinetic (PBPK) model of the GLP-1 inhibitor...

Huelya will develop a physiologically based pharmacokinetic (PBPK) model of the ACE inhibitor captopril.

Frances works on a physiologically based pharmacokinetic (PBPK) model of sorafenib for systemic treatment of hepatocellular carcinoma (HCC). Key questions are to study the...

Sankha worked on the analysis and quantification of microcirculation data recorded in Humans and Rats, developing a workflow for the analysis of orthogonal polarization...

Xenia works on a physiologically based pharmacokinetic (PBPK) model of inulin to assess the glomerular filtration rate (GFR). Our goal is to gain a...

Zahra works on a physiologically based pharmacokinetic (PBPK) model to estimate the glomerular filtration rate (eGFR) using creatinine. The objective is to enhance our...

Adrian worked on a physiologically based model of indocyanine green (ICG) clearance. Key questions are the effect of blood flow and plasma proteins on...

Nurudeen works on a physiologically based pharmacokinetic (PBPK) model of the contrast agent Gd-EOB-DTPA. Key questions are to study the effect of hepatorenal impairment,...

Jan worked on the stratification and personalization of computational models. He develops methods and software for semi-automatic data curation of pharmacokinetic information and a...

Sophie worked on a systematic overview of the protein variability of ABC and SLC transporters in the human liver.

Paula works on a pharmacokinetics/pharmacodynamics model of metoprolol. Key questions are the effect of dosing and formulation on metoprolol pharmacokinetics and exercise heart rate...

Janosch works on the computational modeling of acetaminophen through the liver and curates data for the pharmacokinetics database PK-DB.

Sükrü Balci works on a physiologically based model of omeprazole. Key questions are the effect of omeprazole formulation and dosing on the pharmacodynamic effects...

Yannick Duport works on a physiologically based model of midazolam clearance. Key questions are the effect of inhibitors and inducers on the metabolism of...

Danny Ke works on a physiologically based model of benzodiazepines. Key questions are the effect of genetic variance on clearance of diazepam.

Florian works on a physiologically based model of statin clearance. Key questions are the effect of statins (atorvastatin and simvastatin) on cholesterol plasma levels...

Sara de Angelis works on a physiologically based model of torasemide. Key questions are the effect of sex on torasemide pharmacokinetics and pharmacodynamics.

In cooperation with Andreas Dräger from the University of Tübingen we are extending SBML and JSON support for cobrapy. The full proposal is available...

In cooperation with Andreas Dräger from the University of Tübingen we are extending SBML support for The Systems Biology Simulation Core Library. The full...

In cooperation with Andreas Dräger from the University of Tübingen we are working on the extension of ModelPolisher to a universal annotation tool.

Patrick works on the analysis of mammalian circadian clock in the human liver based on the analysis of OMICS datasets.

Within his thesis the concept of an Modular Research Environment (MRE) was developed. An MRE is a modular application framework that can be extended...

The Systems Biology Simulation Core Library (SBSCL) provides an efficient and exhaustive Java™ implementation of methods to interpret the content of models encoded in...

Within this project as part of Google Summer of Code 2017 a Web App for SBML models was implemented which provides functionality for time...

Dimitra (Master Toxicology) worked on the analysis and digitalization of literature data for liver function tests.