People
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Dr. Matthias König![]() ![]() |
Group leader 2016- |
Data scientist, data analyst, computational modeller, bioinformatician, group leader. Application of computational modelling and machine learning to biological, medical, and clinical questions and datasets. Predictive modeling of physiological processes and systems with focus on metabolic research. Research projects on glucose homeostasis in normal subjects and diabetes, personalization of liver function tests for the improvement of diagnosis, and stratification and individualization of computer models for precision medicine. |
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Jan Grzegorzewski![]() ![]() |
Ph.D. student 2017- |
Jan works on the stratification and personalization of computational models. He develops methods and software for semi-automatic data curation of pharmacokinetics information and a pharmacokinetics database for the storage and FAIR access of such data (PK-DB). | |
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Helen Leal Pujol![]() |
Bachelor student 2021- |
Helen Leal Pujol works on a physiological based model of pravastatin. Key questions are the effect of genotypes and hepatic and renal disease on pravastatin pharmacokinetics. | |
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Jonas Küttner![]() |
Master student 2022- |
Jonas Küttner works on a physiological based model of chlorzoxazone for hepatic CYP2E1 phenotyping. Key questions are the effect of CYP2E1 induction/inhibition and zonation on phenotyping using chlorzoxazone. | |
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Beatrice Stemmer Mallol![]() |
Bachelor student 2022- |
Beatrice Stemmer Mallol works on a physiological based model for the characterization of intestinal P-glycoprotein using talinolol as a probe drug. | |
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Adrian Köller![]() |
Bachelor student, student assistant 2020- |
Adrian Köller works on a physiological based model of indocyanine green (ICG) clearance. Key questions are the effect of blood flow and plasma proteins on ICG clearance and corresponding liver function tests. | |
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Florian Bartsch![]() |
Bachelor student, student assistant 2020- |
Florian Bartsch works on a physiological based model of statin metabolism clearance. Key questions are the effect of statins (atorvastatin and simvasting) on cholesterol plasma levels, and drug-drug interactions due to medications. | |
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Paula Ogata![]() |
Humboldt Intership Student 2020-2021 |
Paula Ogata works on a pharmacokinetics/pharmacodynamics model of metorpolol. Key questions are the effect of dosing and formulation on metoprolol pharmacokinetics and reduction in exercise heart rate (EHR). | |
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Deepa Maheshvare![]() |
Ph.D. student (internship) 2019- |
Deepa Maheshvare works on a kinetic model of the pancreatic beta-cell. Key questions are the effect of various amino acids on the insulin secretion of the pancreas. |
Alumni
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Janosch Brandhorst![]() |
Student assistant 2019-2022 |
Janosch Brandhorst works on the computational modeling of paracetamol by the liver and curating data for PKDB. | |
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Sükrü Balci![]() |
Bachelor student 2020-2021 |
Sükrü Balci works on a physiological based model of omeprazole. Key questions are the effect of omeprazole formulation and dosing on the pharmacodynamic effects of omeprazole. | |
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Sankha Das![]() |
Google summer of code student (2021) 2021 |
In cooperation with Ralf Steuer from the Humboldt-University Berlin we are implementing an SBML report for Humans in sbmlutils. The full proposal is available here. | |
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Yannick Duport![]() |
Bachelor student 2019-2021 |
Yannick Duport works on a physiological based model of midazolam clearance. Key questions are the effect of inhibitors and inducers on the metabolism of midazolam. | |
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Danny Ke![]() |
Humboldt Internship Student 2020 2020-2021 |
Danny Ke works on a physiological based model of benzodiazepines. Key questions are the effect of genetic variance on clearance of diazepam. | |
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Sara de Angelis![]() |
Humboldt Internship Student 2020 2020 |
Sara de Angelis works on a physiological based model of torasemide. Key questions are the effect of sex on torasemide pharmacokinetics and pharmacodynamics. | |
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Hemant Yadav![]() |
Google summer of code student (2020) 2020 |
In cooperation with Andreas Dräger from the University of Tübingen we are extending SBML and JSON support for cobrapy. The full proposal is available here. | |
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Hemil Panchiwala![]() |
Google summer of code student (2020) 2020 |
In cooperation with Andreas Dräger from the University of Tübingen we are extending SBML support for The Systems Biology Simulation Core Library. The full proposal is available here. | |
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Kaustubh Trivedi![]() |
Google summer of code student (2019) 2019 |
In cooperation with Andreas Dräger from the University of Tübingen we are working on the extension of ModelPolisher to a universal annotation tool. | |
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Patrick Pett![]() |
Ph.D. student (mentoring) 2017-2019 |
Patrick works on the analysis of mammalian circadian clock in the human liver based on the analysis of OMICS datasets. | |
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Roman Schulte![]() |
Bachelor thesis 2018 |
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Shalin Shah![]() |
Google Summer of Code 2018 2018 |
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Takahiro Yamada![]() |
Google Summer of Code 2017 2017 |
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Dimitra Eleftheriadou |
Student assistant 2016-2017 |
Dimitra (Master Toxicology) worked on the analysis and digitalization of literature data for liver function tests. |