Dr. Matthias König

Junior Group Leader
LiSyM - Systems Medicine of the Liver
Institute for Biology, Institute for Theoretical Biology
Humboldt Universität zu Berlin
Invalidenstraße 110, 10117 Berlin, Germany
+49 30 2093-98435
koenigmx@hu-berlin.de

   

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konigmatt
0000-0003-1725-179X
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Publons

Matthias König (PhD. in Biophysics) leads an independent junior research group for Systems Biology and Systems Medicine of the liver with focus on metabolic research at the Humboldt University Berlin. His research areas include computational modeling, data science, development of bioinformatics methods and machine learning based on biological, medical and clinical data for predictive modeling of physiological processes and systems. He has been actively involved in the development of SBML, SED-ML and software supporting these standards: Lead-developer of cy3sbml and sbmlutils; co-developer of the SBML simulation software libroadrunner and tellurium.
Key projects are the personalized evaluation of liver function tests and multi-scale modeling of the liver. For more information have a look at our projects.

COMBINE coordinator (2018-)

Our lab works actively on the standardization and reproducibility of computational models in biology. The 'COmputational Modeling in BIology' NEtwork (COMBINE) is an initiative to coordinate the development of the various community standards and formats for computational models.

SBML editor (2018-2020, 2021-2023)

Systems Biology Markup Language (SBML) is a free and open interchange format for computer models of biological processes. SBML is useful for models of metabolism, cell signaling, and more. It continues to be evolved and expanded by an international community.

SED-ML editor (2017-2019, 2020-2022)

The Simulation Experiment Description Markup Language (SED-ML) is an XML-based format for encoding simulation setups, to ensure exchangeability and reproducibility of simulation experiments.

Funding

           

Participation in Research Projects

2016-2020		Junior group leader in Systems Medicine of the Liver project funded by the Federal Ministry of Education and Research (BMBF).
2010-2015		PhD in Systems Biology and Systems Medicine of liver project funded by the Federal Ministry of Education and Research (BMBF).
2005-2010		Student assistant and PhD in Systems Biology and Systems Medicine of liver project funded by the Federal Ministry of Education and Research (BMBF).

Publications

2021		Jan Grzegorzewski, Florian Bartsch, Adrian Köller, and Matthias König Pharmacokinetics of caffeine: A systematic analysis of reported data for application in metabolic phenotyping and liver function testing bioRxiv 2021.07.12.452094; doi: https://doi.org/10.1101/2021.07.12.452094 [preprint, 2021-07-13]
2021		Panchiwala, H.; Shah, S.; Planatscher, H.; Zakharchuk, M.; König, M.; Dräger, A. The Systems Biology Simulation Core Library Preprints 2020, 2020120296 (doi: 10.20944/preprints202012.0296.v1), [In revision, Bioinformatics]
2021		Bruno Christ∗, Maximilian Collatz*, Uta Dahmen*, Karl-Heinz Herrmann*, Sebastian Höpfl*, Matthias König*, Lena Lambers*, Manja Marz*, Daria Meyer*, Nicole Radde*, Jürgen R. Reichenbach*, Tim Ricken*, and Hans-Michael Tautenhahn* (* equal contribution) Hepatectomy-induced alterations in hepatic perfusion and function - Towards multi-scale modeling for a better risk assessment in liver surgery [Submitted to Frontiers Physiology, 2021-06-30]
2021		Adrian Köller, Jan Grzegorzewski, Michael Tautenhahn, Matthias König Prediction of survival after hepatectomy using a physiologically based pharmacokinetic model of indocyanine green liver function tests bioRxiv 2021.06.15.448411; doi: https://doi.org/10.1101/2021.06.15.448411, [Submitted to Frontiers Physiology 2021-06-30]
2021		Bilal Shaikh, Andrew Philip Freiburger, Matthias König, Frank T. Bergmann, David P. Nickerson, Herbert M. Sauro, Michael L. Blinov, Lucian P. Smith, Ion I. Moraru, Jonathan R. Karr SED-ML Validator: tool for debugging simulation experiments arXiV, 2021, 2106.00844, [Submitted to Bioinformatics 2021-06-02]
2021		Adrian Köller (supervisor: Matthias König) A Physiologically Based Model of Indocyanine Green Liver Function Tests - Effects of Physiological Factors, Hepatic Disease and Hepatic Surgery Bachelor Thesis, March 2021
2020		Tim Ricken, Lena Lambers, Bruno Christ, Uta Dahmen, Karl-Heinz Herrmann, Matthias König, Manja Marz, Nicole Radde, Jürgen R. Reichenbach, Lars Ole Schwen & Hans-Michael Tautenhahn QuaLiPerF – Multi-X Liver Modelling GACM - German Association for Computational Mechanics Report, winter 2020: No. 13
2020		Florian Bartsch (supervisor: Matthias König) Computational Modelling of Simvastatin - Effects on HMG-CoA Reductase Activity and Cholesterol Bachelor Thesis, November 2020
2020		Yannick Duport (supervisor: Matthias König) Computational Modelling of Midazolam Clearance: Effect of Inhibitors and Inducers Bachelor Thesis, August 2020
2020		Grzegorzewski J, Brandhorst J, Green K, Eleftheriadou D, Duport Y, Barthorscht F, Köller A, Ke DYJ, De Angelis S, König M. PK-DB: pharmacokinetics database for individualized and stratified computational modeling Nucleic Acids Res. 2020 Nov 5:gkaa990. doi: 10.1093/nar/gkaa990. Epub ahead of print. PMID: 33151297
2020		SM Keating, D Waltemath, M König, F Zhang, A Dräger, C Chaouiya, FT Bergmann, A Finney, CS Gillespie, T Helikar, S Hoops, RS Malik-Sheriff, SL Moodie, II Moraru, CJ Myers, A Naldi, BG Olivier, S Sahle, JC Schaff, LP Smith, MJ Swat, DT, L Watanabe, DJ Wilkinson, ML Blinov, K Begley, JR Faeder, HF Gómez, TM Hamm, Y Inagaki, W Liebermeister, AL Lister, D Lucio, E Mjolsness, CJ Proctor, K Raman, N Rodriguez, CA Shaffer, BE Shapiro, J Stelling, N Swainston, N Tanimura, J Wagner, M Meier-Schellersheim, HM Sauro, B Palsson, H Bolouri, H Kitano, Akira Funahashi, H Hermjakob, JC Doyle M Hucka, and SBML Community members SBML Level 3: an extensible format for the exchange and reuse of biological models Mol Syst Biol. 2020;16(8):e9110. doi:10.15252/msb.20199110
2020		Neal ML, Gennari JH, Waltemath D, Nickerson DP, König M Open modeling and exchange (OMEX) metadata specification version 1.0 J Integr Bioinform. 2020;/j/jib.ahead-of-print/jib-2020-0020/jib-2020-0020.xml. doi:10.1515/jib-2020-0020
2020		F. Schreiber, B. Sommer, G. Bader, P. Gleeson, M. Golebiewski, T. Gorochowski, M. Hucka, S. Keating, M. König, C. Myers, D. Nickerson, D. Walthemath Specifications of Standards in Systems and Synthetic Biology:Status and Developments in 2020 J Integr Bioinform. 2020;/j/jib.ahead-of-print/jib-2020-0022/jib-2020-0022.xml; doi:10.1515/jib-2020-0022
2020		D Waltemath, M Golebiewski, M Blinov, P Gleeson, H Hermjakob, E Inau, S Keating, M König, O Krebs, R Malik-Sheriff, D Nickerson, E Oberortner, H Sauro, F Schreiber, L Smith, M Stefan, U Wittig, C Myers The first 10 years of the international coordination network for standards in systems and synthetic biology (COMBINE) J Integr Bioinform. 2020;/j/jib.ahead-of-print/jib-2020-0005/jib-2020-0005.xml. doi:10.1515/jib-2020-0005
2020		L Smith, S Moodie, F Bergmann, C Gillespie, S Keating, M. König, C Myers, M Swat, D Wilkinson, M Hucka The Distributions Package for SBML Level 3 J Integr Bioinform. 2020 Aug 4;/j/jib.ahead-of-print/jib-2020-0018/jib-2020-0018.xml. doi: 10.1515/jib-2020-0018
2020		Christian Lieven, Moritz Emanuel Beber, Brett G. Olivier, Frank T. Bergmann, Meric Ataman, Parizad Babaei, Jennifer A. Bartell, Lars M. Blank, Siddharth Chauhan, Kevin Correia, Christian Diener, Andreas Dräger, Birgitta Elisabeth Ebert, Janaka N. Edirisinghe, Jose P. Faria, Adam Feist, Georgios Fengos, Ronan M. T. Fleming, Beatriz Garcia-Jimenez, Vassily Hatzimanikatis, Wout van Helvoirt, Christopher Henry, Henning Hermjakob, Markus J. Herrgard, Hyun Uk Kim, Zachary King, Jasper Jan Koehorst, Matthias König, Steffen Klamt, Edda Klipp, Meiyappan Lakshmanan, Nicolas Le Novere, Dong-Yup Lee, Sang Yup Lee, Sunjae Lee, Nathan E. Lewis, Hongwu Ma, Daniel Machado, Radhakrishnan Mahadevan, Paulo Maia, Adil Mardinoglu, Greg L. Medlock, Jonathan Monk, Jens Nielsen, Lars K. Nielsen, Juan Nogales, Intawat Nookaew, Osbaldo Resendis, Bernhard Palsson, Jason A. Papin, Kiran Raosaheb Patil, Mark Poolman, Nathan D. Price, Anne Richelle, Isabel Rocha, Benjamin Sanchez, Peter Schaap, Rahuman S. Malik Sheriff, Saeed Shoaie, Nikolaus Sonnenschein, Bas Teusink, Paulo Vilaca, Jon Olav Vik, Judith A. Wodke, Joana C. Xavier, Qianqian Yuan, Maksim Zakhartsev, Cheng Zhang MEMOTE for standardized genome-scale metabolic model testing Nat Biotechnol. 2020;38(3):272-276. doi: 10.1038/s41587-020-0446-y
2020		Matthias König Executable Simulation Model of the Liver bioRxiv 2020.01.04.894873; doi: https://doi.org/10.1101/2020.01.04.894873 [accepted, 04-2020]
2019		Lambers L., Ricken T., and König M. Model Order Reduction (MOR) of Function-Perfusion-Growth Simulation in the Human Fatty Liver via Artificial Neural Network (ANN) Proceedings in Applied Mathematics & Mechanics, PAMM, 10.1002/pamm.201900429, 2019
2019		F Schreiber, G Bader, P Gleeson, M Golebiewski, M Hucka, SM Keating, M König, C Myers, D Nickerson, B Sommer, D Waltemath Specifications of Standards in Systems and Synthetic Biology: Status and Developments in 2019 J Integr Bioinform. 2019 Jul 13;16(2); 10.1515/jib-2019-0035
2019		M. Hucka, F. Bergmann, C. Chaouiya, A. Dräger, S. Hoops, S. Keating, M. König, N Le Novere, C. Myers, B. Olivier, S. Sahle, J. Schaff, R. Sheriff, L. Smith, D. Waltemath, D. Wilkinson, F. Zhang The Systems Biology Markup Language (SBML): Language Specification for Level 3 Version 2 Core J Integr Bioinform. 2019 Jun 20;16(2); 10.1515/jib-2019-0021
2018		Choi K., Medley K., König M., Stocking K., Smith L., Gu S., and Sauro HM. Tellurium: An Extensible Python-based Modeling Environment for Systems and Synthetic Biology Biosystems. 2018 Jul 24. pii: S0303-2647(18)30125-4. doi: 10.1016/j.biosystems.2018.07.006
2018		Berndt N., Bulik S., Wallach I., Wünsch T., König M., Stockmann M., Meierhofer M., Holzhütter HG. HEPATOKIN1: A Biochemistry-Based Model of Liver Metabolism Suited for Applications in Medicine and Pharmacology Nat Commun. 2018 Jun 19;9(1):2386. doi: 10.1038/s41467-018-04720-9.
2018		Bergmann, FT., Cooper, J., König, M.*, Moraru, I., Nickerson, D., Le Novère N., Olivier, BG., Sahle, S., Smith, L., Waltemath, D. * corresponding author Simulation Experiment Description Markup Language (SED-ML) Level 1 Version 3 (L1V3) J Integr Bioinform. 2018 Mar 19;15(1); doi: 10.1515/jib-2017-0086
2018		Neal, M.; König, M.; Nickerson, D.; Misirli, G.; Kalbasi, R.; Dräger, A.; Atalag, K.; Chelliah, V.; Cooling, M.; Cook, D.; Crook, S.; de Alba, M.; Friedman, S.; Garny, A.; Gennari, J.; Gleeson, P.; Golebiewski, M.; Hucka, M.; Juty, N.; Novère, N. L.; Myers, C.; Olivier, B.; Sauro, H.; Scharm, M.; Snoep, J.; Touré, V.; Wipat, A.; Wolkenhauer, O. & Waltemath, D. Harmonizing semantic annotations for computational models in biology Brief Bioinform. 2018 Nov 21. doi: 10.1093/bib/bby087
2018		Watanabe L.*, König* M., and Myers C. * equal contribution Dynamic Flux Balance Analysis Models in SBML bioRxiv 245076; doi: doi.org/10.1101/245076 [submitted]
2018		Medley K., Choi K., König M., Smith L., Gu S., Hellerstein J., Sealfon S., and Sauro HM. Tellurium Notebooks — An Environment for Reproducible Dynamical Modeling in Systems Biology. PLoS computational biology 14, no. 6 (2018): e1006220.; doi: 10.1371/journal.pcbi.1006220
2017		Christ, B.*, Dahmen, U.*, Herrmann, K.H.*, König, M.*, Reichenbach, J.R*., Ricken, T.*, Schleicher, J.*, Ole Schwen, L.*, Vlaic, S.* and Waschinsky, N.* * equal contribution Computational Modeling in Liver Surgery Frontiers in physiology, 8, p.906; doi: 10.3389/fphys.2017.00906
2016		König M.*, Oellrich A.*, Waltemath D.*, Dobson R., Hubbard T., and Wolkenhauer O. * equal contribution Challenges and opportunities for system biology standards and tools in medical research ODLS, p1-6, 2016; article
2016		König M. cy3sabiork: A Cytoscape app for visualizing kinetic data from SABIO-RK [version 1; referees: awaiting peer review]. F1000Research 2016, 5:1736 (doi: 10.12688/f1000research.9211.1)
2016		Choi K., Medley JK., Cannistra C., König M., Smith L., Stocking K., and Sauro HM. Tellurium: A Python Based Integrated Environment for Biological Modeling and Simulation bioRxiv 054601; doi: doi.org/10.1101/054601
2016		Wholecell Consortium (König M.) Toward community standards and software for whole-cell modeling IEEE Trans Biomed Eng. 2016 Jun 10. [PubMed]
2015		Kerstin A.*, König M.*, Hoppe A., Thomas M., Müller I., Ebert M., Weng H., Holzhütter HG., Zanger UM., Bode J., Vollmar B. and Dooley S. * equal contribution Pathobiochemical signatures of cholestatic liver disease in bile duct ligated mice BMC Syst Biol. 2015 Nov 20;9(1):83. doi: 10.1186/s12918-015-0229-0 [PubMed]
2015		Werner D., Ricken T., Dahmen U., Dirsch O., Holzhütter HG., König M. On the Influence of Growth in Perfusion Dependent Biological Systems - at the Example of the Human Liver. PAMM 15 (1), 119-120, 2015 [doi:10.1002/pamm.201510050]
2015		Somogyi ET., Bouteiller JM., Glazier JA., König M., Medley JK., Swat MH and Sauro HM. LibRoadRunner: a high performance SBML simulation and analysis library. Bioinformatics. 2015 Jun 17. pii: btv363. [PubMed]
2014		Ricken T., Werner D., Holzhütter HG., König M., Dahmen U., Dirsch O. Modeling function-perfusion behavior in liver lobules including tissue, blood, glucose, lactate and glycogen by use of a coupled two-scale PDE-ODE approach. Biomech Model Mechanobiol. 2014 Sep 19. [doi, PubMed]
2014		König M. and Holzhütter HG. Homeostasis of blood glucose - Computer simulations of central liver functions. systembiologie.de 2014; 8:p.53-57 [PDF (de), PDF (en)]
2013		König M., Holzhütter HG., Berndt N. Metabolic Gradients as Key Regulators in Zonation of Tumor Energy Metabolism: A Tissue-scale Model Based Study. Biotechnol J. 2013 Apr 16. [doi, PubMed]
2012		König M. and Holzhütter HG. Kinetic Modeling of Human Hepatic Glucose Metabolism in T2DM Predicts Higher Risk of Hypoglycemic Events in Rigorous Insulin Therapy J Biol Chem. 2012 [DOI 10.1074/jbc.M112.382069]
2012		König M., Dräger A. and Holzhütter HG. CySBML: a Cytoscape plugin for SBML Bioinformatics. 2012 Jul 5. [PubMed]
2012		König M., Bulik S. and Holzhütter HG. Quantifying the Contribution of the Liver to the Homeostasis of Plasma Glucose: A Detailed Kinetic Model of Hepatic Glucose Metabolism Integrated with the Hormonal Control by Insulin, Glucagon and Epinephrine PLoS Comput Biol. 2012 Jun;8(6):e1002577. Epub 2012 Jun 21. [PubMed]
2011		Herling A, König M, Bulik S, Holzhütter HG. Enzymatic Features of the Glucose Metabolism in Tumor Cells. FEBS J. 2011 Jul;278(14):2436-59. [doi, PubMed]
2011		König M. and Holzhütter HG. FluxViz - Cytoscape Plug-in for Vizualisation of Flux Distributions in Networks Genome Informatics 2010, Vol.24, p.96-103 [PubMed]
2010		Gille C, Bölling C, Hoppe A, Bulik S, Hoffmann S, Hübner K, Karlstädt A, Ganeshan R, König M, Rother K, Weidlich M, Behre J, Holzhütter HG. HepatoNet1: a comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology. Mol Syst Biol., 6:411. [PubMed]